Pimobendan 74150-27-9 Metabolism PDE inhibitor

Product name:  Pimobendan Synonyms:  4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone CAS No.: 74150-27-9 Quality: USP43 Molecular formula: C19H18N4O2 Molecular weight: 334.37

Products Details

Payment: T/T, L/C Product Origin: China Shipping Port: Beijing/Shanghai/Hangzhou Order (MOQ): 1g Lead Time: 3 working days Production capacity: 1kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: vial, bottle Package size: 1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle Safety information:  UN 2811 6.1/PG 3

Item

Specification

Appearance

White or slightly yellowish powder, hygroscopic

Mp

About 242℃

Solubility

Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetoneand in methanil.

Identification

Infrared absorption spectrophotometry, Comparison pimobendan CRS.

The retention time of the major peak of the Sample solution corresponds to that of the Standard stock solution,as obtained in the Organic Impurities test.

Heavy metals

≤10ppm

Granularity

P90 ≤ 25μ m

Particle size

20-80 mesh

Residual solvents

≤ 500ppm

Water

≤ 1.0%

Assay

98.0%~102.0%

Sulphated ash

≤ 0.10%

Related substances (HPLC)

impurity A

≤ 0.10%

impurity B

≤ 0.10%

Any other impurity

≤ 0.10%

Total impurity

≤ 0.20%

Pimobendan, is a veterinary medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator effects. Pimobendan is used in the management of heart failure in dogs, most commonly caused by myxomatous mitral valve disease (also previously known as endocardiosis), or dilated cardiomyopathy. Research has shown that as a monotherapy, pimobendan increases survival time and improves quality of life in canine patients with congestive heart failure secondary to mitral valve disease when compared with benazepril, an ACE inhibitor.

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