Doramectin, with the chemical formula C50H74O14 and the CAS number 117704-25-3, is a macrocyclic lactone antiparasitic agent that is widely used in veterinary medicine. It is derived from avermectin, which is produced by the soil bacterium Streptomyces avermitilis. Doramectin is an effective treatment for a range of internal and external parasites in cattle, sheep, goats, and swine. It works by binding to glutamate-gated chloride ion channels in the neuromuscular system of parasites, causing paralysis and ultimately death. It is particularly useful in the control of gastrointestinal nematodes and mange mites. One of the key advantages of doramectin is its long half-life, which allows for extended protection against parasitic infestations. It is also relatively safe for use in animals, with few adverse effects reported. Doramectin is typically administered via injection, and a number of formulations are available for different species and indications. It is important to follow proper dosage and administration guidelines to ensure effective treatment and minimize the risk of resistance. Overall, doramectin is a valuable tool for managing parasitic infestations in livestock, helping to improve animal health, welfare, and productivity. With its potent activity and favorable safety profile, it is likely to remain a key component in the veterinary toolbox for years to come.

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